Train: Get off at Wiesbaden HbF and take the Bus (description below).
Bus: Bus line no. 8 towards Schiersteiner Straße and exit at Waldstrasse. It is a 10 minutes walk from there.
Walk in the direction of bus towards left and turn next street right Waldstrasse.
Walk to the end (200m) until you reach the round-abound.
Another option will be the bus line No 18 or E18 towards exit Kuenstlerviertel/Homburger Strasse.
This exit will be only 50m away from the round-abound. BUT - please let the bus driver know ahead that you want to leave there.
Bus does a return on the round-abound and the next exit then will be 300 m further away.
Car: Just put the above link into your favorite direction finder and let Ms. Google provide instructions.
Parking: Leave round-abound first exit (Homburger Strasse) and turn next left (Carla-Henius-Strasse) and find a parking spot there.
Street parking or anywhere else you feel comfortable with.